幽门螺杆菌粘附素研究进展

粘附定居是细菌感染不可缺少的致病过程.幽门螺杆菌(Helicobacterpylori,简称Hp)要侵及胃粘膜需有Hp定植因子,包括动力、尿素酶活性和粘附素[1].研究表明,粘附素是Hp重要毒力因子之一[2-5],可与胃粘膜上皮上的特异受体结合,是其得以致病的先决条件.现对目前Hp粘附素的相关研究作一综述.     

Obesity in bipolar disorder and major depressive disorder: results from a national community health survey on mental health and well-being.

OBJECTIVE: We aimed to ascertain the prevalence of obesity in individuals with a mood disorder (MD) (that is, bipolar disorder or major depressive disorder), compared with the general population. We further aimed to examine the likelihood of an association between obesity and MD, while controlling for the influence of sociodemographic variables. METHOD: The analysis was based on data from Statistics Canada's Canadian Community Health Survey: Mental Health and Well-Being (CCHS 1.2), conducted in 2002. The sample (n = 36 984; > or = aged 15 years) was drawn from the Canadian household-dwelling population. The CCHS used diagnostic criteria outlined in the DSM-IV to screen respondents. RESULTS: Individuals with a lifetime history of MD were more likely to be obese (body mass index [BMI] > 30) than were individuals without lifetime MD (19%, compared with 15%, respectively; P < 0.001). In sex-specific multivariate analysis, lifetime MD was associated with elevated odds of obesity in female respondents (95%CI, 1.03 to 1.46, odds ratio 1.22), but not in male respondents. Antipsychotic pharmacotherapy was also associated with obesity. CONCLUSIONS: This is the first Canadian epidemiologic investigation to specifically evaluate anthropometric indices and associated factors in people with MDs. The results herein supplement substantial clinical evidence documenting the association between MDs and stress-sensitive somatic disorders (for example, obesity). These data also underscore the metabolic consequences of some psychotropic agents.     

1999年和2000年医院内细菌耐药监测结果分析

目的：对医院内临床标本中分离菌进行耐药性监测，为细菌性感染经验治疗提供依据。方法：药敏试验用K-B纸片法，根据1999年美国临床实验室标准化委员会（NCCLS）标准判断结果，应用WHONET-5软件对临床分离细菌的药敏结果进行统计。结果：所监测抗生素均有不同程度的耐药。结论：规范的细菌耐药性监测工作对医院感染菌治疗十分必要。     

盐酸塞利洛尔合成工艺改进

目的:合成盐酸塞利洛尔,并进行工艺改进。方法:革除溴化反应,对醚化反应进行了优化。结果:使合成路线缩短一步,醚化收率比文献值提高20％以上。结论:该路线较适合于工业化生产。     

The psychological and social condition of hypertensives resistant to pharmacological treatment.

To characterize patients with therapy-resistant essential hypertension (TR) from a psychosocial point of view, 29 hypertensives, filling specified criteria for TR in a hypertension clinic were selected out of 800 patients screened. A control group of patients with established, but well controlled hypertension, pair-wise matching study patients for age and gender was also selected. TR patients were predominantly of working-class origin (68 vs 19% P less than 0.001). They tended to be more obese (BMI 28.7 +/- 5.5 vs 26.9 +/- 3.9 ns). TR tended to report fewer important life events, and reported significantly fewer positive events from the last 10 year period P less than 0.05. According to the EAI, their ability to channel emotions, especially anger, was impaired (P less than 0.01). So was their instrumental handling of emotions such as anger and sorrow (P less than 0.05). They experienced less of joy, and even had a more negative attitude towards that emotion (P less than 0.05). When adjusted for social class this latter difference was not statistically significant. Their degree of global emotional differentiation was lower (P less than 0.05). In the ISSI interview they had low scores for availability of emotional attachment (P less than 0.01), and friendship (P less than 0.05), but not for social integration. To conclude, when compared to well controlled hypertensives, TR exhibited the pattern, which has been shown to characterize young, asymptomatic, hypertensives in comparison to healthy subjects. These results must not be overinterpreted due to the limited sample.(ABSTRACT TRUNCATED AT 250 WORDS)     

Craniofacial and dental findings in cystinosis

Oral Diseases (2010) 16 , 488–495 Objectives: Cystinosis is a rare autosomal recessive lysosomal storage disorder with developmental and mineralization anomalies as part of its clinical presentation. The objective of this study was to provide the first systematic assessment of the craniofacial and dental characteristics associated with cystinosis. Study Design: Oral and radiographic evaluations were performed on 73 patients with cystinosis. Analyses of cephalometry (n = 20), taurodontism (n = 47), caries (n = 47), enamel defects (n = 48), soft tissue anomalies (n = 48), and dental age (n = 41) were performed on the cystinosis group, and compared with age‐ and sex‐comparable controls or standards. Results: Cystinosis patients manifested relative mandibular deficiency, an increased facial height, and a reduced airway space. Taurodontism and enamel defects were significantly more prevalent in cystinosis patients compared with controls (P < 0.0001 and P = 0.027, respectively). Children (aged <15 years) with cystinosis also demonstrated a significant delay, of almost 9 months, of their dental development (P < 0.001). Conclusion: Novel craniofacial and dental features are associated with cystinosis. Craniofacial deficiencies may influence the swallowing and respiratory complications seen in cystinosis. Renal pathology and associated mineral imbalance may explain the dental root and enamel anomalies found in cystinosis patients; the developmental delays in cystinosis include delayed dental formation.     

以右下腹软组织感染为首发症状的卵巢癌1例

1临床资料患者女性,65岁,绝经15 a,因右下腹疼痛、局部皮肤红肿3 d在当地医院诊治,考虑右下腹软组织感染,给予抗炎治疗,效果不佳.1 mo后发现右下腹肿块,于2004-12-11转来我院就诊.     

Effects of response deprivation on the instrumental performance of mentally retarded persons

The accuracy of the response deprivation and probability differential hypotheses to predict reinforcement effects for mentally retarded persons was evaluated. Fifteen individuals listened to music and looked at slides in baseline phases, in reinforcement schedules and in control phases with no contingent relation between the responses. Individual analysis of instrumental responding indicated increases in those schedules that produced response deprivation but only once in schedules that did not, regardless of the probability differential between responses. The conclusions were that the response deprivation hypothesis identified the necessary and sufficient conditions for producing reinforcement for retarded persons and that this hypothesis might provide an alternative approach to reinforcer selection for retarded individuals.     

Comorbidity in bipolar disorder: a framework for rational treatment selection

Bipolar disorders are heterogeneous disorders often requiring multimodality treatment. The expanding pharmacopeia for bipolar disorders invites the need for a treatment framework that both recognizes and anticipates the multidimensionality and comorbidity of the illness. No available neurotherapeutic agent is singularly efficacious for the complete mélange of bipolar symptomatology. An apparent paradox has emerged in the management of bipolar disorder; whilst results from rigorous controlled monotherapy trials suggest that a disparate assortment of neurotherapeutic agents are efficacious in distinct phases of bipolar disorder, the majority of tertiary-treated bipolar patients receive polypharmacotherapeutic regimens. The evidentiary base for polypharmacotherapy is sparse and has recently become an area of active research focus. In the interim, clinicians are encouraged to invoke an organizational schema for the treatment of bipolar disorder that considers the spectrum of effectiveness of putative and established mood stabilizers. This schema should be further informed by the treatment data for comorbid and accessory conditions. The authors propose a schema to provide the impetus for further work in the area.